The Basket Case
Basket Case is a 1982 American horror film written and directed by Frank Henenlotter in his feature directorial debut. Produced by Edgar Ievins, the film stars Kevin Van Hentenryck as Duane Bradley, a young man who seeks vengeance on the doctors and nurses who performed an unwanted surgery that separated him from his deformed conjoined twin brother Belial, whom Duane hides in a large wicker basket.
The Basket Case
Duane Bradley arrives in New York City with a locked wicker basket. He gets a room at a cheap hotel right down the hall from a sex worker named Casey. He takes some hamburgers and feeds them to a creature in his basket which talks to him telepathically. When Duane is out the next day a man named Brian O'Donovan looks through Duane's keyhole in order to steal Duane's wad of money. Casey scares him off and informs Duane about it. Duane takes his basket to see Dr. Harold Needleman and befriends his assistant Sharon. Needleman contacts Dr. Judith Kutter and tells her about Duane's visit and Lifflander's death, but she ignores him. Duane goes back to Needleman's that night and empties the creature, who is revealed to be his twin brother Belial,[a] onto the floor. Belial kills Needleman by gutting him with his claws.
The next day, Duane goes to meet Sharon at the Statue of Liberty and they kiss. Belial senses this and trashes the hotel room in a temper tantrum. He hides when the hotel manager opens the door to see what the commotion is. O'Donovan sneaks back inside to steal Duane's money but is killed by Belial when he opens the basket. Duane senses the attack telepathically and hurries back. Duane tells Belial that he deserves some time for himself. Duane, with the basket, run into Casey at a bar and drunkenly tells her that Belial is his twin brother.
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Duane Bradley arrives in New York City with a locked basket. After he gets a room at a cheap hotel, the contents of the basket are finally revealed: in it lives his deformed Siamese twin brother, Belial. Although conjoined at birth, the twins are surgically separated at an early age against their will, and Belial deeply resents being cut off from his normal-looking brother. As the twins seek revenge against the doctors responsible for their separation, Duane befriends a nurse, Susan. Jealous, Belial attacks and kills her, frustrated with his inability to rape her. Enraged at his brother for his actions, Duane attempts to kill Belial, which results in the two brothers falling from a hotel window.
Now together, the family are forced to hide from the authorities, as their reputation has become uproarious in the world. Ruth orders Duane to avoid the vicinity of his malignant brother, as it is unsafe for them to be together while they are at stake. However, Belial meets a female monster who looks just like him and has libido on him and they make love. Belial has now a bundle of baby beasts who he wants to protect by any means. Duane is later captured by Sheriff Griffin, who is using him as an odalisque in order to get information from him about about his brother. However, he is rescued as a basket is delivered into the office, containing Bradley and tortures and murders the people. With the cops all down Ruth and her people attack places in the world and sends broadcast on TV telling the world that the freaks have now control over the world. If they ever get belittled, oppressed, opposed or humiliated those who do will be killed. After Ruth informs the vital info, she ends by saying; Have a nice day.
What's in the basket? The debut gutter-trash symphony from Frank Henenlotter (Brain Damage, Frankenhooker), stealthily filmed in the toilet bowls of Times Square and chock-full of demented fury. Hilarious, disgusting, and over-the-top in every way possible, this movie plays out like Herschell Gordon Lewis directing Freaks on the set of Taxi Driver. A true homemade classic.
Duane and his brother Belial are ex-siamese twins who arrive in New York with a purpose -- REVENGE! Against everyone! That's enough to propel any movie, but here the deal is even sweeter because Belial is a telepathic monstrosity who lives in a wicker basket. Basket Case features an incredibly grotesque monster puppet that will burn its essence on the surface of your brain until the day you die. It's also filled with real-life 42nd Street sleazers, stop-motion shocks and non-stop sicko fun.
Duane Bradley arrives in New York from the small town of Glenn Falls, to the ugly Hotel Broslin. Anthony, the hotel manager, mocks him and asks for twenty bucks a night. Duane is loaded, pays in cash and is given room 7. On her way up, Josephine chit-chats about the old guest in his room. Once inside his room, Duane unlocks his basket and feeds it a huge quantity of hamburgers. Duane reads a thick volume of medical papers, where he appears as a patient. At night, Belial, the body in the basket, tries to talk to him, but Duane only wants to sleep. We know that Belial can leave the basket on his own. Casey warns Duane that Brian Mickey O'Donovan was peeping through the keyhole because he saw the wad of bills which Duane had.
Duane takes the basket to see Dr. Harold Needleman MD. Receptionist Sharon tries to make small conversation with Duane, who sees Dr. Needleman under the name of Duane Smith. Duane rejects Sharon at first, but then he asks for her number and sets on a date. Needleman looks at the huge scars on the right side of Duane's body. When Needleman gets rid of Duane, he tries to contact Lifflander and when he can't, he phones Dr. Judith Kutter, who reminds him to deny any knowledge of Glen Falls.
Duane goes to the cinema to see a martial arts film and dozes off. A thief steals the basket and is attacked by Belial when he opens the basket. After Sharon has left, Duane leaves and opens the box. Belial is free to terrorize and kill Needleman, and also takes Needleman's address book.
Duane takes the basket to a bar, where he gets drunk, while Casey keeps him company. Duane spills his life story to her, but she doesn't believe him. Duane talks about their mother, who died giving birth to them. He and Belial were brought up by their aunt, as their father would like to kill them both, especially Belial. A social worker visits them, as Aunt has asked for custody. She is terrified when he sees a younger Duane with Belial at his right side of the body. Father thinks that Belial is not even a person. No doctor dares to try to separate both twin brothers, as it would mean the death of Belial, but finally, three doctors perform the surgery. At night, Duane is woken up. He picks Belial up from a rubbish bag put out with the rest of the rubbish. That night, when Belial recovers, kills Father by cutting him in half. Aunt will keep on taking care of the brothers. After this story, back at the Broslin Hotel, Casey puts Duane to bed and leaves. Back on her room, Casey realizes that Belial is there, caressing her. She screams and wakes all the guests up. Belial is gone fast. He has stolen Casey's underwear, and takes it with him to his basket.
Dr. Kutter is a veterinarian. A dog barks at the basket in the waiting room. With plenty of noise and blood, Belial kills her. Sharon visits Duane after she comes to know that Dr. Needleman is dead. They try to make love but Belial doesn't want Duane to have or sex, or be in love, or be independent. Duane gets angry with Belial for the first time. Belial hesitates in killing Duane.
For years, Frank Henenlotter was adamant that there could be no sequel to Basket Case (1985) because the audience knew what was in the basket, all of the doctors had been killed and Duane and Belial were dead.
Ukraine was known as the breadbasket of the Soviet Union for its fertile fields of wheat. Now it's just a basket case. The outgoing finance minister said the country needed $35 billion to stave off bankruptcy over the next couple years.
A basket clinical trial takes a collection of conditions that share a similar trait (such as a specific biomarker or perhaps a particular genetic characteristic) and tests a single treatment on all of them to determine if that agent works better for one compared to the others. A schematic of a basket trial can be seen in panel B in the image below):
An alternative to a basket trial is an umbrella study, which takes a single condition and tests different drugs on it (see panel A in the image above), with the drug allocation being determined by the presence of particular biomarkers in each participant. The key in both basket and umbrella studies are the biomarkers used.